FOX04-DRI 10mg For Sale

FOXO4-DRI is a synthetic D-retro-inverso peptide designed to target cellular senescence, a key driver of aging and age-related disease. By disrupting the interaction between FOXO4 and p53, it selectively induces apoptosis in senescent cells while sparing healthy ones. This senolytic mechanism reduces the harmful pro-inflammatory secretions of these cells, thereby restoring tissue homeostasis and improving regenerative capacity. Unlike many experimental senotherapeutics, FOXO4-DRI has demonstrated targeted action with a favorable safety profile in preclinical models. It is being investigated for its potential to extend healthspan, support organ repair, and reduce the burden of degenerative and metabolic diseases associated with aging.

Friendly reminder: All peptides come in a pure, lyophilized (freeze-dried) form. Bacteriostatic Water is required to reconstitute the peptide. We do sell Bacteriostatic water in our store.

Key Research Areas:

Senolytic & Healthy Aging
Demonstrates selective clearance of senescent cells by disrupting FOXO4–p53 binding, reducing their harmful secretions (SASP) and improving systemic tissue function.
Tissue Regeneration & Repair
By removing dysfunctional cells from the regenerative niche, supports stem cell renewal, muscle recovery, and organ repair capacity.
Neuroprotection & Cognitive Health
Clearing senescent cells in neural tissue reduces neuroinflammation and oxidative stress, with potential benefits for age-related cognitive decline and neurodegenerative disorders.
Metabolic & Inflammatory Balance
Associated with lower chronic inflammation and improved metabolic signaling, positioning it for study in cardiovascular, renal, and metabolic disease contexts.
Cancer-Adjacency Research
Investigated for its ability to reduce tumor-promoting microenvironments created by senescent cells, supporting ongoing interest in cancer prevention and adjunctive strategies.
Geroprotective Applications
Considered a leading candidate in senotherapeutics, with broad implications for extending healthspan, delaying degenerative changes, and promoting resilience in aging tissues.

Product Care and Storage – All products are shipped using the Lyophilization process, which ensures that products remain stable for shipping for up to 3-4 months. Products must be reconstituted to a liquid, by mixing with bacteriostatic water for research and testing.
Lyophilized or powder form – Store in cool, dry place away from light; can be stored at room temperature. Remains stable for several weeks or more.
For long term storage (months to years) freezing is optimal to preserve stability and maintain integrity.
Reconstituted form – Refrigerate under 39F; peptides will remain stable for up to 30 days.
Usage – We are unable to provide any dosing instructions, however all products should be considered pharmaceutical grade.
Disclaimer – This product is for research use only and is not intended for human consumption, diagnostic use, or clinical treatment. Proper laboratory safety protocols should always be followed when handling peptides.